New strong fibrates with piperidine moiety

  • Chem Pharm Bull (Tokyo). 2000 Dec;48(12):1978-85. doi: 10.1248/cpb.48.1978.
T Komoto  1 ,  T K Hirota ,  M Otsuka ,  J Kotake ,  S Hasegawa ,  H Koya ,  S Sato ,  T Sakamoto
Affiliations
PMID: 11145154 DOI: 10.1248/cpb.48.1978
Abstract

New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxyl-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, Cholesterol, and blood sugar compared to bezafibrate in mice and rats.

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