3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

  • Bioorg Med Chem Lett. 2001 Jan 22;11(2):183-5. doi: 10.1016/s0960-894x(00)00635-1.
Y Kashiwada  1 ,  J Chiyo ,  Y Ikeshiro ,  T Nagao ,  H Okabe ,  L M Cosentino ,  K Fowke ,  K H Lee
Affiliations
PMID: 11206454 DOI: 10.1016/s0960-894x(00)00635-1
Abstract

Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.