Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten

  • Arch Pharm Res. 2001 Feb;24(1):51-4. doi: 10.1007/BF02976493.
Y N Han  1 ,  Y Choo ,  Y C Lee ,  Y I Moon ,  S D Kim ,  J W Choi
Affiliations
  • 1. Natural Products Research Institute, Seoul National University, Korea. [email protected]
PMID: 11235812 DOI: 10.1007/BF02976493
Abstract

Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioassay-guided isolation for the inhibition on Monoamine Oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.

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