RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

  • Bioorg Med Chem Lett. 2001 Mar 12;11(5):693-6. doi: 10.1016/s0960-894x(01)00034-8.
A J Collis  1 ,  M L Foster ,  F Halley ,  C Maslen ,  I M McLay ,  K M Page ,  E J Redford ,  J E Souness ,  N E Wilsher
Affiliations
  • 1. Aventis Pharma, Dagenham Research Centre, Essex, UK.
PMID: 11266171 DOI: 10.1016/s0960-894x(01)00034-8
Abstract

Following the discovery of RPR200765, a series of pyrimidine analogues have been prepared as backups. Amongst them, RPR203494 was identified with a better in vitro profile than RPR200765A.

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