Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar

  • J Nat Prod. 2001 May;64(5):563-8. doi: 10.1021/np000517o.
D Guilet  1 ,  J J Hélesbeux ,  D Séraphin ,  T Sévenet ,  P Richomme ,  J Bruneton
Affiliations
  • 1. SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49100 Angers, France.
PMID: 11374944 DOI: 10.1021/np000517o
Abstract

Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known Coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.