Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1749-52. doi: 10.1016/s0960-894x(01)00297-9.
T M Tagmose  1 ,  J P Mogensen ,  P C Agerholm ,  P O Arkhammar ,  P Wahl ,  A Worsaae ,  J B Hansen
Affiliations
  • 1. Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
PMID: 11425552 DOI: 10.1016/s0960-894x(01)00297-9
Abstract

3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of Insulin release from pancreatic beta cells in vitro.