Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota

  • Phytochemistry. 2001 Sep;58(1):153-7. doi: 10.1016/s0031-9422(01)00177-7.
K P Manfredi  1 ,  V Vallurupalli ,  M Demidova ,  K Kindscher ,  L K Pannell
Affiliations
  • 1. Department of Chemistry, University of Northern Iowa, Cedar Falls, IA 50614, USA. [email protected]
PMID: 11524125 DOI: 10.1016/s0031-9422(01)00177-7
Abstract

The organic soluble extract from the leaves of Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete 1H NMR and 13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay.

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