Synthesis and bioactivities of novel 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1beta) production

  • Bioorg Med Chem Lett. 2001 Sep 3;11(17):2373-5. doi: 10.1016/s0960-894x(01)00433-4.
T Matsuda  1 ,  T Aoki ,  T Koshi ,  M Ohkuchi ,  H Shigyo
Affiliations
  • 1. Tokyo Research Laboratories, Kowa Company Ltd., 2-17-43, Noguchi-Cho, Higashimurayama, Tokyo 189-0022, Japan. [email protected]
PMID: 11527734 DOI: 10.1016/s0960-894x(01)00433-4
Abstract

New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described.