Synthesis of hydantocidin and C-2-thioxo-hydantocidin

  • Carbohydr Res. 2001 Oct 8;335(3):147-50. doi: 10.1016/s0008-6215(01)00239-7.
M Shiozaki  1
Affiliations
  • 1. Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Hiromachi 1-2-58, Shinagawa-ku, 140-8710, Tokyo, Japan. [email protected]
PMID: 11578630 DOI: 10.1016/s0008-6215(01)00239-7
Abstract

Hydantocidin, a naturally occurring strong Herbicide, was synthesized in an overall yield of 35.2%, with the accompanying 1'-epi-hydantocidin in overall 9.6% yield from 2,3-O-isopropylidene-D-ribono-1,4-lactone. C-2-thioxo-hydantocidin and its spiro-epimer were also synthesized in an overall yield of 14.4% and 8.5%, respectively.

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