(+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids

  • J Nat Prod. 2001 Oct;64(10):1357-9. doi: 10.1021/np0102859.
L F Villegas  1 ,  A Marçalo ,  J Martin ,  I D Fernández ,  H Maldonado ,  A J Vaisberg ,  G B Hammond
Affiliations
  • 1. Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA.
PMID: 11678668 DOI: 10.1021/np0102859
Abstract

Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-alpha-bisabolol (1) (ED(50) 155 microg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, alpha-bisabolol (2) and alpha-terpineol (3) (ED(50) of 228 and 240 microg/g mouse[corrected], respectively).