7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma

  • Bioorg Med Chem Lett. 2002 Feb 11;12(3):509-12. doi: 10.1016/s0960-894x(01)00786-7.
George M Buckley  1 ,  Nicola Cooper ,  Richard J Davenport ,  Hazel J Dyke ,  Fiona P Galleway ,  Lewis Gowers ,  Alan F Haughan ,  Hannah J Kendall ,  Christopher Lowe ,  John G Montana ,  Janet Oxford ,  Joanna C Peake ,  C Louise Picken ,  Marianna D Richard ,  Verity Sabin ,  Andrew Sharpe ,  Julie B H Warneck
Affiliations
  • 1. Celltech R & D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
PMID: 11814830 DOI: 10.1016/s0960-894x(01)00786-7
Abstract

The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).