Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes

  • J Med Chem. 2002 Mar 14;45(6):1374-8. doi: 10.1021/jm010473w.
Yoshiaki Hamada  1 ,  Hidekazu Tokuhara ,  Araki Masuyama ,  Masatomo Nojima ,  Hye-Sook Kim ,  Kanako Ono ,  Naoki Ogura ,  Yusuke Wataya
Affiliations
  • 1. Department of Materials Chemistry & Frontier Research Center, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
PMID: 11882006 DOI: 10.1021/jm010473w
Abstract

Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).