CJ-21,058, a new SecA inhibitor isolated from a fungus

  • J Antibiot (Tokyo). 2002 Jan;55(1):25-9. doi: 10.7164/antibiotics.55.25.
Yutaka Sugie  1 ,  Sae Inagaki ,  Yoshinao Kato ,  Hiroyuki Nishida ,  Chang-Hong Pang ,  Toshiyuki Saito ,  Shinichi Sakemi ,  Fadia Dib-Hajj ,  John P Mueller ,  Joyce Sutcliffe ,  Yasuhiro Kojima
Affiliations
  • 1. Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. [email protected]
PMID: 11918061 DOI: 10.7164/antibiotics.55.25
Abstract

A new equisetin derivative, CJ-21,058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows Antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a Bacterial cell membrane.

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