Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

  • Bioorg Med Chem Lett. 2002 May 6;12(9):1295-8. doi: 10.1016/s0960-894x(02)00140-3.
Pierre Deprez  1 ,  Eliane Mandine ,  Dominique Gofflo ,  Stéphane Meunier ,  Dominique Lesuisse
Affiliations
  • 1. Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. [email protected]
PMID: 11965374 DOI: 10.1016/s0960-894x(02)00140-3
Abstract

Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.

Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-W994722
    ISO24
    Src SH2 Ligand
    target: Src
    Research Areas: Cancer