Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline

  • J Nat Prod. 2002 Apr;65(4):566-9. doi: 10.1021/np010298m.
R M Kariba  1 ,  P J Houghton ,  Abiy Yenesew
Affiliations
  • 1. Department of Botany and Department of Chemistry, University of Nairobi. P.O. Box 30197, Nairobi, Kenya.
PMID: 11975502 DOI: 10.1021/np010298m
Abstract

Extracts from Schizozygia coffaeoides showed antimicrobial activity against Fungal and Bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19beta-hydroxyschizozygine, shown to be the most active Antifungal compound. The structure of isoschizagaline, the only active Antibacterial, is revised on the basis of NMR analysis.

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