Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma

  • J Nat Prod. 2002 Apr;65(4):616-7. doi: 10.1021/np010440j.
Bang Yeon Hwang  1 ,  Jeong-Hyung Lee ,  Jeong Bum Nam ,  Hang Sub Kim ,  Young Soo Hong ,  Jung Joon Lee
Affiliations
  • 1. Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
PMID: 11975517 DOI: 10.1021/np010440j
Abstract

Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of Peroxisome Proliferator-activated Receptor gamma (PPARgamma) with an EC(50) value of 16.7 microM; however, saurufuran B (2), with an EC(50) value of >100 microM, weakly activated the PPARgamma.

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