Shikonin derivatives: synthesis and inhibition of human telomerase

  • Bioorg Med Chem Lett. 2002 May 20;12(10):1375-8. doi: 10.1016/s0960-894x(02)00158-0.
Qun Lu  1 ,  Weijun Liu ,  Jian Ding ,  Junchao Cai ,  Wenhu Duan
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Science, 200031, Shanghai, PR China.
PMID: 11992780 DOI: 10.1016/s0960-894x(02)00158-0
Abstract

We synthesized DL-shikonin, shikonin, alkanin, and their cyclo-derivatives and acyl-derivatives. These compounds have low cytotoxicity, as well as inhibitory activity against the Telomerase enzyme, except cyclo-derivatives.