Abietane diterpenoids from Coleus xanthanthus

  • J Nat Prod. 2002 May;65(5):633-7. doi: 10.1021/np0102049.
Shuang-Xi Mei  1 ,  Bei Jiang ,  Xue-Mei Niu ,  Ma-Lin Li ,  Hui Yang ,  Zhi Na ,  Zhong-Wen Lin ,  Chao-Ming Li ,  Han-Dong Sun
Affiliations
  • 1. Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, People's Republic of China.
PMID: 12027731 DOI: 10.1021/np0102049
Abstract

Eight new abietane Diterpenoids, coleon U 11-acetate (1), 16-acetoxycoleon U 11-acetate (2), and xanthanthusins F-K (3-8), together with five known analogues, coleon U (9), 16-O-acetylcoleon C (10), coleon U-quinone (11), 8alpha,9alpha-epoxycoleon U-quinone (12), and xanthanthusin E (13), were isolated from the aerial parts of Coleus xanthanthus. The structures of 1-8 were elucidated on the basis of spectral methods. Compounds 1, 5, and 11-13 were evaluated for their cytotoxicity against K562 human leukemia cells.