Novel bicyclic oxazolone derivatives as anti-angiogenic agents

  • Bioorg Med Chem Lett. 2002 Jun 3;12(11):1463-6. doi: 10.1016/s0960-894x(02)00197-x.
Françoise M Perron-Sierra  1 ,  Alain Pierré ,  Mike Burbridge ,  Nicolas Guilbaud
Affiliations
  • 1. Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France. [email protected]
PMID: 12031320 DOI: 10.1016/s0960-894x(02)00197-x
Abstract

Novel bicyclic tetrahydropyrano[3,2-d]oxazolones derivatives, analogues of Fumagillin, were synthesised via a stereocontrolled oxidative-rearrangement of furylcarbinols and subsequent treatment with the appropriate isocyanate. These compounds demonstrated potent antiangiogenic activity.