Nicotinanilides as inhibitors of neutrophil chemotaxis

  • Bioorg Med Chem Lett. 2002 Jun 3;12(11):1517-20. doi: 10.1016/s0960-894x(02)00188-9.
Neil S Cutshall  1 ,  Kristin A Kucera ,  Rocky Ursino ,  John Latham ,  Nathan C Ihle
Affiliations
  • 1. Department of Chemistry, Celltech R&D Inc., 1631 220th Street SE, Bothell, WA 98021, USA. [email protected]
PMID: 12031332 DOI: 10.1016/s0960-894x(02)00188-9
Abstract

A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.