8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma

  • Bioorg Med Chem Lett. 2002 Jun 17;12(12):1613-5. doi: 10.1016/s0960-894x(02)00223-8.
George M Buckley  1 ,  Nicola Cooper ,  Hazel J Dyke ,  Fiona P Galleway ,  Lewis Gowers ,  Alan F Haughan ,  Hannah J Kendall ,  Christopher Lowe ,  Robert Maxey ,  John G Montana ,  Robert Naylor ,  Janet Oxford ,  Joanna C Peake ,  C Louise Picken ,  Karen A Runcie ,  Verity Sabin ,  Andrew Sharpe ,  Julie B H Warneck
Affiliations
  • 1. Celltech R&D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
PMID: 12039574 DOI: 10.1016/s0960-894x(02)00223-8
Abstract

A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).