A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues

  • Org Lett. 2002 Jun 13;4(12):2091-3. doi: 10.1021/ol020073i.
T G Murali Dhar  1 ,  Junqing Guo ,  Zhongqi Shen ,  William J Pitts ,  Henry H Gu ,  Bang-Chi Chen ,  Rulin Zhao ,  Mark S Bednarz ,  Edwin J Iwanowicz
Affiliations
  • 1. Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA. [email protected]
PMID: 12049525 DOI: 10.1021/ol020073i
Abstract

[structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.

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