Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship

  • Bioorg Med Chem Lett. 2002 Sep 2;12(17):2303-7. doi: 10.1016/s0960-894x(02)00431-6.
Vedula M Sharma  1 ,  P Prasanna ,  K V Adi Seshu ,  B Renuka ,  C V Laxman Rao ,  G Sunil Kumar ,  C Prasad Narasimhulu ,  P Aravind Babu ,  R C Puranik ,  D Subramanyam ,  A Venkateswarlu ,  Sriram Rajagopal ,  K B Sunil Kumar ,  C Seshagiri Rao ,  N V S Rao Mamidi ,  Dhanvanthri S Deevi ,  R Ajaykumar ,  R Rajagopalan
Affiliations
  • 1. Discovery Chemistry (Natural Products), Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India. [email protected]
PMID: 12161121 DOI: 10.1016/s0960-894x(02)00431-6
Abstract

In our endeavor to design and synthesize novel Anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for Anticancer activity in vitro against a panel of human Cancer cell lines. Most of these compounds exhibited cytotoxic activity in in vitro screens. Compounds were selected and further evaluated using a modified Hollow Fiber Assay for their preliminary in vivo activity against 12 cell lines implanted in the subcutaneous and intraperitoneal compartments in mice. The results indicate that these compounds may constitute a new class of Anticancer agents.