Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice

  • Bull Exp Biol Med. 2002 Jan;133(1):68-70. doi: 10.1023/a:1015164713174.
A A Mikhailova  1 ,  E A Kirilina ,  O V Morozova ,  V S Turusov
Affiliations
  • 1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
PMID: 12170311 DOI: 10.1023/a:1015164713174
Abstract

We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treatment with myelopeptide-2 decreased the number of spontaneous and urethane-induced lung tumors in mice. Myelopeptide-2 delayed the appearance of urethane-induced tumors irrespective of the number of injections.

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