Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin

  • Phytother Res. 2002 Aug;16(5):491-3. doi: 10.1002/ptr.938.
Kan Shimpo  1 ,  Chikako Ida ,  Takeshi Chihara ,  Hidehiko Beppu ,  Takaaki Kaneko ,  Hiroshi Kuzuya
Affiliations
  • 1. Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296, Japan. [email protected]
PMID: 12203274 DOI: 10.1002/ptr.938
Abstract

The ethyl acetate extract of the acetone-soluble Aloe arborescens fraction was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema, putrescine increase and tumour promotion in mouse skin. Chromatographic analyses of this extract revealed that phenolic compounds such as aloenin, barbaloin and isobarbaloin could be useful as Cancer chemopreventive agents against tumour promotion.

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