Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii

  • J Nat Prod. 2002 Sep;65(9):1346-8. doi: 10.1021/np020055+.
Namphung Vongvanich  1 ,  Prasat Kittakoop ,  Masahiko Isaka ,  Srisuda Trakulnaleamsai ,  Saovaluk Vimuttipong ,  Morakot Tanticharoen ,  Yodhathai Thebtaranonth
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
PMID: 12350163 DOI: 10.1021/np020055+
Abstract

A new cyclohexadepsipeptide, named hirsutellide A (1), was isolated from a cell extract of the entomopathogenic fungus Hirsutella kobayasii BCC 1660. The structure of 1 was elucidated by analyses of spectroscopic data, and its absolute stereochemistry was addressed by the use of Marfey's method. Hirsutellide A (1) exhibited antimycobacterial and antimalarial activities, but was inactive toward the Vero cell line (at 50 microg/mL).