Anticancer activity for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and their abilities to interact with lymphoendothelial cell surface markers

  • Bioorg Med Chem Lett. 2002 Dec 2;12(23):3407-11. doi: 10.1016/s0960-894x(02)00725-4.
Lee Roy Morgan  1 ,  Branko S Jursic ,  Catherine L Hooper ,  Donna M Neumann ,  Kanappan Thangaraj ,  Blaise LeBlanc
Affiliations
  • 1. DEKK-TEC, Inc, New Orleans, LA 70119, USA.
PMID: 12419372 DOI: 10.1016/s0960-894x(02)00725-4
Abstract

The structure of the Anticancer agent 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007's moieties. Analogue Anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.