Trifluoromethyl ketones as inhibitors of histone deacetylase

  • Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. doi: 10.1016/s0960-894x(02)00754-0.
Robin R Frey  1 ,  Carol K Wada ,  Robert B Garland ,  Michael L Curtin ,  Michael R Michaelides ,  Junling Li ,  Lori J Pease ,  Keith B Glaser ,  Patrick A Marcotte ,  Jennifer J Bouska ,  Shannon S Murphy ,  Steven K Davidsen
Affiliations
PMID: 12419380 DOI: 10.1016/s0960-894x(02)00754-0
Abstract

Trifluoromethyl ketones were found to be inhibitors of histone deacetylases (HDACs). Optimization of this series led to the identification of submicromolar inhibitors such as 20 that demonstrated antiproliferative effects against the HT1080 and MDA 435 cell lines.