Novel chromone derivatives from the fungus Aspergillus versicolor isolated from the marine sponge Xestospongia exigua

  • J Nat Prod. 2003 Jan;66(1):57-61. doi: 10.1021/np020196b.
Wenhan Lin  1 ,  Gernot Brauers ,  Rainer Ebel ,  Victor Wray ,  Albrecht Berg ,  Sudarsono ,  Peter Proksch
Affiliations
  • 1. Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Geb. 26.23, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
PMID: 12542346 DOI: 10.1021/np020196b
Abstract

From the marine Sponge Xestospongia exigua collected in Indonesia the fungus Aspergillus versicolor was isolated. Following cultivation in a seawater-based medium seven new angular tricyclic chromone derivatives (1-7) were obtained from the mycelia and culture filtrate. Compounds 2-7 contain an additional dihydropyran ring system which is replaced by a pyridine ring in 1. The structures of the new natural products were established on the basis of extensive one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, NOE difference spectra) as well as on mass spectral analysis.

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