Synthesis of milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27, delta(2,3),delta(4,26)-milbemycins A3, A4 from milbemycins A3, A4, and their acaricidal activities

  • J Antibiot (Tokyo). 2002 Nov;55(11):993-1003. doi: 10.7164/antibiotics.55.993.
Takahiro Tsukiyama  1 ,  Hisaki Kajino ,  Fumie Kajino ,  Satoru Furuta ,  Yoshihisa Tsukamoto ,  Kazuo Sato ,  Ayako Kinoshita ,  Reiji Ichinose ,  Keiji Tanaka
Affiliations
  • 1. Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd. 1041 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. [email protected]
PMID: 12546420 DOI: 10.7164/antibiotics.55.993
Abstract

Chemical derivation methods to prepare 26-acyloxy and 26-hydroxymilbemycins, which had been reported as natural products, milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27 from milbemycins A3, A4 were reported. Delta(2,3),delta(4,26)-milbemycins A3, A4, which had also been reported as natural products, were further prepared from milbemycins A3, A4. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider Mite (Tetranychus urticae) on primary leaves of cowpea Plants (Vigna sinesis Savi species) by spraying.

Products