Enflurane as an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry

  • J Chromatogr A. 2003 Jan 24;985(1-2):259-64. doi: 10.1016/s0021-9673(02)01223-2.
Antonio Accorsi  1 ,  Simona Valenti ,  Anna Barbieri ,  Giovanni Battista Raffi ,  Francesco Saverio Violante
Affiliations
  • 1. Safety, Hygiene and Occupational Medicine Service, University of Bologna, Via Pelagio Palagi 9, Bologna, 40138 Italy. [email protected]
PMID: 12580493 DOI: 10.1016/s0021-9673(02)01223-2
Abstract

Recently. we proposed the use of a run-only headspace-GC-MS method for the biological monitoring of ppb concentrations of unmodified volatile anaesthetics (isoflurane, sevoflurane and halothane, plus nitrous oxide) in post-shift urine of operating theatre personnel. The adoption of enflurane (a volatile anaesthetic no longer used in clinical practice) as a poper and viable internal standard improves intra-day and inter-day accuracy in halide quantitation, providing a GC-MS reference method useful in the practice of biomonitoring of exposure of operating theatre personnel to modern volatile anaesthetics (isoflurane. sevoflurane, halothane).

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