Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity

  • Bioorg Med Chem Lett. 2003 Mar 24;13(6):1107-10. doi: 10.1016/s0960-894x(03)00025-8.
Andrew Cooke  1 ,  Alison Anderson ,  Jonathan Bennett ,  Kirsteen Buchanan ,  David Gemmell ,  Niall Hamilton ,  Maurice Maidment ,  Petula McPhail ,  Donald Stevenson ,  Hardy Sundaram
Affiliations
  • 1. Department of Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Scotland, ML1 5SH, UK. [email protected]
PMID: 12643922 DOI: 10.1016/s0960-894x(03)00025-8
Abstract

A novel series of alpha-amino-acid phenolic ester derivatives containing sulphide, sulphoxide, sulphone, ester and amide side chains were prepared and shown to display potent intravenous anaesthetic activity.

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