Substituted bridged phenyl piperidines: orally active growth hormone secretagogues

  • Bioorg Med Chem Lett. 2003 May 19;13(10):1817-20. doi: 10.1016/s0960-894x(03)00261-0.
Zhijian Lu  1 ,  James R Tata ,  Kang Cheng ,  Liente Wei ,  Wanda W-S Chan ,  Bridget Butler ,  Klaus D Schleim ,  Thomas M Jacks ,  Gerard Hickey ,  Arthur A Patchett
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. [email protected]
PMID: 12729672 DOI: 10.1016/s0960-894x(03)00261-0
Abstract

A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and in vivo. The synthesis and biological activity of these compounds are discussed.