Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety

  • Bioorg Med Chem Lett. 2003 Jun 16;13(12):2059-63. doi: 10.1016/s0960-894x(03)00258-0.
Edwin J Iwanowicz  1 ,  Scott H Watterson ,  Junqing Guo ,  William J Pitts ,  T G Murali Dhar ,  Zhongqi Shen ,  Ping Chen ,  Henry H Gu ,  Catherine A Fleener ,  Katherine A Rouleau ,  Daniel L Cheney ,  Robert M Townsend ,  Diane L Hollenbaugh
Affiliations
  • 1. Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12781195 DOI: 10.1016/s0960-894x(03)00258-0
Abstract

The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell proliferation (for select analogues) are given.