Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line

  • J Med Chem. 2003 Jul 17;46(15):3185-8. doi: 10.1021/jm020548b.
Yuka Nakanishi  1 ,  Fang-Rong Chang ,  Chih-Chuang Liaw ,  Yang-Chang Wu ,  Kenneth F Bastow ,  Kuo-Hsiung Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.
PMID: 12852747 DOI: 10.1021/jm020548b
Abstract

Several bioactive acetogenins were selective against 1A9 (ovarian Cancer) cell replication but did not show a corresponding hyperactivity against Other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for Other cell lines.