Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase

  • Bioorg Med Chem Lett. 2003 Oct 6;13(19):3297-300. doi: 10.1016/s0960-894x(03)00553-5.
Zakaria Rachid  1 ,  Athanasia Katsoulas ,  Fouad Brahimi ,  Bertrand Jacques Jean-Claude
Affiliations
  • 1. Cancer Drug Research Laboratory, Division of Medical Oncology, Department of Medicine, McGill University/Royal Victoria Hospital, 687 Pine Avenue West Rm M-719, Montreal, Québec, Canada H3A 1A1.
PMID: 12951113 DOI: 10.1016/s0960-894x(03)00553-5
Abstract

The synthesis and abl tyrosine kinase inhibitory activities of alkyltriazenes conjugated to phenylaminopyrimidines are described. Significant abl inhibitory activities were observed only when a benzamido spacer was inserted between the 1,2,3-triazene chain and the 2-phenyaminopyridopyrimidine moiety.