Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system

  • Mutat Res. 1992 Feb;281(2):143-7. doi: 10.1016/0165-7992(92)90050-r.
P Rubiolo  1 ,  L Pieters ,  M Calomme ,  C Bicchi ,  A Vlietinck ,  D Vanden Berghe
Affiliations
  • 1. Dipartimento di Scienza e Technologia del Farmaco, Universitá delgi Studi di Torino, Turin, Italy.
PMID: 1370983 DOI: 10.1016/0165-7992(92)90050-r
Abstract

The mutagenicity of a series of Pyrrolizidine Alkaloids, and of extracts from several Italian Senecio species containing Pyrrolizidine Alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.

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