Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents

  • Bioorg Med Chem Lett. 2003 Oct 20;13(20):3451-4. doi: 10.1016/s0960-894x(03)00743-1.
Ahmed Kamal  1 ,  G Ramesh ,  P Ramulu ,  O Srinivas ,  Tasneem Rehana ,  G Sheelu
Affiliations
  • 1. Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. [email protected]
PMID: 14505647 DOI: 10.1016/s0960-894x(03)00743-1
Abstract

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some Cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.