New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth

  • J Asian Nat Prod Res. 2003 Dec;5(4):241-7. doi: 10.1080/1028602031000105849.
Hong-Wei Liu  1 ,  San-Long Wang ,  Bin Cai ,  Ge-Xia Qu ,  Xu-Juan Yang ,  Hisayoshi Kobayashi ,  Xin-Sheng Yao
Affiliations
  • 1. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Wenhua-Road 103, Shenyang 110016, China.
PMID: 14604232 DOI: 10.1080/1028602031000105849
Abstract

Two new furostanol glycosides, 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-23(S)-methoxyl-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl(1 --> 2)-[beta-D-glucopyranosyl(1 --> 3)]-beta-D-glucopyranoside (dioscoreside E, 1) and 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-Lrhamnopyranosyl(1 --> 2)-[beta-D-glucopyranosyl (1 --> 3)]-beta-D-glucopyranoside (prtotogracillin, 2), together with 11 known furostanol glycosides were isolated from the rhizomes of Dioscorea futshauensis R. Kunth. Their structures were elucidated on the basis of spectroscopic analysis (NMR and FABMS). Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 Cancer cell line were evaluated in vitro.

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