Antimycobacterial and antioxidant flavones from Limnophila geoffrayi

  • Arch Pharm Res. 2003 Oct;26(10):816-20. doi: 10.1007/BF02980026.
Apichart Suksamrarn  1 ,  Ponsuda Poomsing ,  Nuntana Aroonrerk ,  Tadsanee Punjanon ,  Sunit Suksamrarn ,  Somkiat Kongkun
Affiliations
  • 1. Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. [email protected]
PMID: 14609129 DOI: 10.1007/BF02980026
Abstract

The chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the Flavones nevadensin (5,7-dihydroxy-6,8,4'-trimethoxyflavone, 1) and isothymusin (6,7-dimethoxy-5,8,4'-trihydroxyflavone, 2). Both compounds 1 and 2 exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. Only compound 2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the IC50 value of 7.7 microg/mL. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay.

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