beta-alanine dipeptides as MC4R agonists

  • Bioorg Med Chem Lett. 2003 Dec 15;13(24):4341-4. doi: 10.1016/j.bmcl.2003.09.036.
Réjean Ruel  1 ,  Timothy F Herpin ,  Lawrence Iben ,  Guanglin Luo ,  Alain Martel ,  Helen Mason ,  Gail Mattson ,  Brigitte Poirier ,  Edward H Ruediger ,  Dan Shi ,  Carl Thibault ,  Guixue Yu ,  Ildiko Antal Zimanyi ,  Graham S Poindexter ,  John E Macor
Affiliations
  • 1. Bristol-Myers Squibb Pharmaceutical Research Institute, 100 boul. de l'Industrie, Candiac, Quebec, Canada J5R 1J1. [email protected]
PMID: 14643322 DOI: 10.1016/j.bmcl.2003.09.036
Abstract

beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.