Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c]benzodiazepine hybrids

  • Bioorg Med Chem Lett. 2004 Jan 19;14(2):471-4. doi: 10.1016/j.bmcl.2003.10.050.
Ahmed Kamal  1 ,  G Ramesh ,  O Srinivas ,  P Ramulu
Affiliations
  • 1. Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, 500007, Hyderabad, India. [email protected]
PMID: 14698184 DOI: 10.1016/j.bmcl.2003.10.050
Abstract

Pyrene-linked pyrrolobenzodiazepine hybrids have been synthesized that exhibit potential Anticancer activity in a number of human tumour cell lines. These hybrids also exhibit much enhanced DNA-binding ability in comparison to the parent pyrrolobenzodiazepine ring system (DC-81).