Central action of sigma receptor ligand, JO 1784, to suppress CRF-induced inhibition of gastric function in conscious rats

  • Eur J Pharmacol. 1992 Nov 17;223(2-3):197-9. doi: 10.1016/0014-2999(92)94840-r.
M Yoneda  1 ,  J L Junien ,  Y Taché
Affiliations
  • 1. Veterans Administration Medical Center, Department of Medicine and Brain Research Institute, UCLA 90073.
PMID: 1478267 DOI: 10.1016/0014-2999(92)94840-r
Abstract

The central interaction between the Sigma Receptor ligand, JO 1784, and corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion and emptying was investigated in conscious rats. Intracisternal (i.c.) injection of CRF (5 micrograms) inhibited by 95% gastric acid secretion. JO 1784 (0.05-0.5 micrograms) given i.c. immediately before i.c. injection of CRF partially reversed CRF antisecretory action whereas JO 1784 (5 micrograms) given i.v. had no effect. CRF (0.6 micrograms i.c.)-induced 83% inhibition of gastric emptying was reversed by 45% by JO 1784 (5 micrograms i.c.). JO 1784 (5-50 micrograms i.c.) did not influence basal gastric function. These data demonstrate a centrally mediated antagonistic action of the Sigma Receptor ligand, JO 1784, on i.c. CRF-induced inhibition of gastric function.

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