Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine

  • Bioorg Med Chem Lett. 2004 Mar 8;14(5):1273-7. doi: 10.1016/j.bmcl.2003.12.044.
Dong Rack Choi  1 ,  Jung Han Shin ,  Jin Yang ,  Sue Hye Yoon ,  Yong Ho Jung
Affiliations
  • 1. Central Research Laboratory, Dong-Wha Pharm. Ind. Co. Ltd, Anyang, Kyunggi 430-017, South Korea. [email protected]
PMID: 14980680 DOI: 10.1016/j.bmcl.2003.12.044
Abstract

The design and syntheses of new fluoroquinolone Antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro Antibacterial activities and pharmacokinetic profiles.