Design, synthesis and structure-activity relationship of novel RXR-selective modulators

  • Bioorg Med Chem Lett. 2004 Mar 22;14(6):1593-8. doi: 10.1016/j.bmcl.2003.12.089.
Pierre-Yves Michellys  1 ,  Jennifer D'Arrigo ,  Timothy A Grese ,  Donald S Karanewsky ,  Mark D Leibowitz ,  Dale A Mais ,  Christopher M Mapes ,  Anne Reifel-Miller ,  Deepa Rungta ,  Marcus F Boehm
Affiliations
  • 1. Department of Medicinal Chemistry, Ligand Pharmaceuticals Incorporated, 10275 Science Center Drive, San Diego, CA 92121, USA. [email protected]
PMID: 15006411 DOI: 10.1016/j.bmcl.2003.12.089
Abstract

The synthesis and in vitro characterization of novel RXR-selective ligands possessing various substituted 1-benzofuran or 1-benzothiophene moieties are described.