Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells

  • J Med Chem. 2004 Mar 25;47(7):1595-8. doi: 10.1021/jm034257u.
Fabio Carraro  1 ,  Annalisa Pucci ,  Antonella Naldini ,  Silvia Schenone ,  Olga Bruno ,  Angelo Ranise ,  Francesco Bondavalli ,  Chiara Brullo ,  Paola Fossa ,  Giulia Menozzi ,  Luisa Mosti ,  Fabrizio Manetti ,  Maurizio Botta
Affiliations
  • 1. Dipartimento di Fisiologia, Unità di Fisiologia Cellulare e Molecolare, Università degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy.
PMID: 15027847 DOI: 10.1021/jm034257u
Abstract

Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast Cancer cells 8701-BC, known to overexpress Src. The ability of such compounds to significantly reduce 8701-BC cell proliferation suggests that this scaffold could be a promising lead for the development of antitumoral agents able to block Src phosphorylation of breast Cancer cells.