Biscoumarin: new class of urease inhibitors; economical synthesis and activity

  • Bioorg Med Chem. 2004 Apr 15;12(8):1963-8. doi: 10.1016/j.bmc.2004.01.010.
Khalid Mohammed Khan  1 ,  Sajid Iqbal ,  Muhammad Arif Lodhi ,  Ghulam Murtaza Maharvi ,  Zia Ullah ,  Muhammad Iqbal Choudhary ,  Atta-Ur Rahman ,  Shahnaz Perveen
Affiliations
  • 1. H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. [email protected]
PMID: 15051064 DOI: 10.1016/j.bmc.2004.01.010
Abstract

A variety of biscoumarins (1-21) with variable substituents at C-11 were synthesized with an improved method and evaluated as Urease inhibitors. The synthesized compounds showed varying degree of Urease inhibitory activity ranging from 15.06-91.35 microM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the Urease inhibitors.

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