In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase

  • Bioorg Med Chem Lett. 2004 Jun 21;14(12):3155-9. doi: 10.1016/j.bmcl.2004.04.015.
Derek B Lowe  1 ,  Steven Magnuson ,  Ning Qi ,  Ann-Marie Campbell ,  James Cook ,  Zhenqiu Hong ,  Ming Wang ,  Mareli Rodriguez ,  Furahi Achebe ,  Harold Kluender ,  Wai C Wong ,  William H Bullock ,  Arthur I Salhanick ,  Terri Witman-Jones ,  Mary E Bowling ,  Christine Keiper ,  Kevin B Clairmont
Affiliations
  • 1. Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. [email protected]
PMID: 15149665 DOI: 10.1016/j.bmcl.2004.04.015
Abstract

A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive Lipase, an enzyme of potential importance in the treatment of diabetes.