Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs

  • Bioorg Med Chem Lett. 2004 Jun 21;14(12):3221-6. doi: 10.1016/j.bmcl.2004.03.095.
Ben B Wang  1 ,  Nima Maghami ,  Vanessa L Goodlin ,  Paul J Smith
Affiliations
  • 1. Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
PMID: 15149679 DOI: 10.1016/j.bmcl.2004.03.095
Abstract

Three new analogs of UK-1 have been synthesized and their efficacies as Topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of Topo II and identifies a critical structure motif necessary for enzyme inhibition.