Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity

  • Bioorg Med Chem Lett. 2004 Oct 4;14(19):4907-9. doi: 10.1016/j.bmcl.2004.07.036.
Ahmed Kamal  1 ,  R Ramu ,  G B Ramesh Khanna ,  Ajit Kumar Saxena ,  M Shanmugavel ,  Renu Moti Pandita
Affiliations
  • 1. Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. [email protected]
PMID: 15341949 DOI: 10.1016/j.bmcl.2004.07.036
Abstract

New pyrrolobenzodiazepine-anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many Cancer cell lines